The TOXEM laboratory, specialising in medical genotoxicity, was commissioned to demonstrate the non mutagenicity of the ADN-Telomeractives© product.


The purpose of this experiment was to determine the possibly mutagenic potential of the ADN-Téloméractives© sample. This mutagenic potential is determined using the Ames fluctuation assay (Ames assay in a liquid medium). The Ames fluctuation assay has proved to be an excellent test for determining the carcinogenic potential of a chemical substance based on its mutagenic properties with respect to DNA. 

The conclusions of this analysis do not reveal any mutagenicity of ADN Téloméractives©, with or without metabolic activation (that is to say with the basic product or when the product has been degraded by digestion), whatever the concentration tested. 

 

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The TOXEM laboratory, specialising in medical genotoxicity, was commissioned to demonstrate the anti-genotoxic potential of the ADN-Telomeractives© product.


SOS-Chromotest is a colorimetric assay that implements a genetically modified strain of e. Coli, in which a partial gene deletion is carried out as well as a fusion with the genes. The ‘SOS’ system is implemented when DNA is damaged. If a defect in the DNA causes any replication, a protein binds to the locked zone and goes into the active state.

Thus, using a specific reagent we measure this activity induction: SOS Induction Factor (SOSIF).

The strain studied was also exposed to a fixed concentration of a reference genotoxic agent as well as to different concentrations of the product whose anti-genotoxic potential we wanted to assess. The anti-genotoxic potential of the ADN Telomeractives® product was measured not only against a direct genotoxic but also a pro-genotoxic agent.

Conclusions: in the presence of direct and pro-genotoxic agents, the DNA Telomeractives® product induced a significant dose-dependent decrease in the SOSIF obtained for this reference genotoxic molecule.

The graphs show a strong potential anti-genotoxic activity (up to four times less genotoxic activity than in the presence of the product according to the concentrations). 


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